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Dr Daniel Forton BSc, PhD, MBBS, MRCP is a
Consultant Hepatologist and Gastroenterologist and
Honorary Senior Lecturer at St George’s Hospital
London.
He qualified at University College London and
trained in Gastroenterology, Hepatology and General
Medicine at St Mary’s, Charing Cross and Hammersmith
Hospitals, London.
During his training he was appointed as a Research
Fellow and subsequently, as a Clinical Lecturer at
Imperial College London, performing scientific
research and clinical trials in the area of viral
hepatitis. He was awarded a PhD from Imperial
College London in 2004. His research has been
presented at international meetings and has been
published widely in peer-reviewed journals. His
current research interests include clinical trials
in liver disease and mechanisms of viral persistence
in chronic hepatitis.
His clinical practice today encompasses all areas of
Gastroenterology and Hepatology, including the
investigation of indigestion, abdominal pain and
change of bowel habit. Dr Forton has particular
interests in the investigation and management of
chronic liver disease and therapeutic endoscopy.
He is skilled in endoscopic retrograde
cholangiopancreatography (ERCP) to diagnose and
treat gallstones and pancreaticobiliary tumours. He
also undertakes other therapeutic procedures
including stricture dilatation, metal stent
insertion, treatment of varices and polypectomy. He
is an accredited provider of colonoscopy for the
National Bowel Cancer Screening Programme.
RESEARCH PUBLICATIONS
- Forton DM,
Hamilton G, Allsop JM, Grover VJ, Wesnes K,
O’Sullivan C, Thomas HC, Taylor-Robinson SD.
Cerebral Immune Activation in Chronic Hepatitis
C Infection: A Magnetic Resonance Spectroscopy
Study. J Hepatol 2008 (in press)
- Forton DM.
Altered monoaminergic transporter binding in
hepatitis C related cerebral dysfunction: a
neuroimmunologial condition? Gut. 2006
55(11):1535-7
- Grover VP,
Dresner MA, Forton DM, Counsell S, Larkamn DJ,
Patel N, Thomas HC, Taylor-Robinson SD. Current
and future applications of magnetic resonance
imaging and spectroscopy of the brain in hepatic
encephalopathy. World J Gastroenterol. 2006
12(19):2969-78
- Forton D,
Karayiannis P. Established and Emerging
Therapies for the Treatment of Viral Hepatitis.
Dig Dis. 2006; 24(1-2):160-73.
- Forton DM,
Taylor-Robinson SD, Thomas HC. Central nervous
system changes in hepatitis C virus infection.
Eur J Gastroenterol Hepatol. 2006 18(4):333-8.
- Forton DM,
Allsop J, Cox IJ, Hamilton G, Wesnes K, Thomas
HC, Taylor-Robinson SD. Cognitive Impairment and
Cerebral Metabolite Abnormalities in Patients
with Mild Hepatitis C-Associated Liver Disease.
AIDS. 2005 19 Suppl 3:S53-63
- Forton DM,
Patel, Prince M, Oatridge A, Hamilton G,
Goldblatt J, Allsop J, Hajnal JV, Thomas HC,
Bassendine M, Jones DEJ, Taylor-Robinson SD.
Fatigue in primary biliary cirrhosis. Gut.
2005
54(3):438.
- Wright M,
Forton DM, Main J, Goldin R, Torok ME, Tedder R,
Grant P, Thursz P, Naoumov N, Milson C, Mills P,
Bassendine, Thomas HC. Treatment of
Histologically Mild Hepatitis C virus Infection
with Interferon and Ribavirin: A Multicentre
Randomised Controlled Trial. J. Viral. Hep. 2005
12(1):58-66.
- Forton DM,
Thomas HC, Taylor-Robinson SD. Central Nervous
System Involvement in Hepatitis C Virus
Infection. Metab Brain Dis. 2004 19(3):383-91.
- Forton DM,
Mahmud N, Taylor-Robinson SD, Karayiannis P,
Thomas HC. Identification of Unique Hepatitis C
Quasispecies in the Central Nervous System and
Comparative Analysis of Internal Translation
Efficiency of Brain, Liver and Serum Variants.
J Virol. 2004 78(10):5170-83.
- Forton DM,
Patel, Prince M, Oatridge A, Hamilton G,
Goldblatt J, Allsop J, Hajnal JV, Thomas HC,
Bassendine M, Jones DEJ, Taylor-Robinson SD.
Fatigue and Primary Biliary Cirrhosis:
Association of Globus Pallidus Magnetization
Transfer Ratio Measurements with Fatigue
Severity and Blood Manganese Levels. Gut.
2004
53(4):587-92.
- Forton DM,
Thomas HC, Taylor-Robinson SD. Quality of life
and cognitive function in chronic hepatitis C –
what to measure? J Hepatol. 2003 39(2):272-4.
- Hamilton G,
Patel N, Forton DM, Hajnal JV, Taylor-Robinson
SD. Prior knowledge for time domain
quantification of in vivo brain or liver 31P MR
spectra. NMR Biomed. 2003 16(3):168-76.
- Mangoni ED,
Forton DM, Ruggiero G, Karayiannis P. Hepatitis
C virus E2 and NS5A region variability during
sequential treatment with two interferon-alpha
preparations. J Med Virol. 2003 70(1):62-73.
- Forton DM,
Taylor-Robinson SD, Thomas HC. Cerebral
dysfunction in chronic hepatitis C infection.
J
Viral Hepat. 2003 10(2):81-6.
- Hamilton G,
Mathur R, Allsop JM, Forton DM, Dhanjal NS, Shaw
RJ, Taylor-Robinson SD. Changes in brain
intracellular pH and membrane phospholipids on
oxygen therapy in hypoxic patients with chronic
obstructive pulmonary disease. Metab Brain Dis.
2003 18(1):95-109
- Forton DM,
Wright M, Knapp S, Thursz M, Taylor-Robinson SD,
Thomas HC. New Insights into Hepatitis C. Clin
Med. 2002;2(6):554-9
- Forton DM,
Taylor-Robinson SD, Thomas HC. Reduced quality
of life in hepatitis C – is it all in the head?
J Hepatol 2002;36:435-8
- Forton DM,
Thomas HC, Murphy CA, Allsop J, Foster GR, Main
J, Wesnes KA, Taylor-Robinson SD. Hepatitis C
and Cognitive Impairment in a Cohort of Patients
with Mild Liver Disease. Hepatology
2002;35:433-9
- Forton DM,
Allsop JM, Main J, Foster GR, Thomas HC,
Taylor-Robinson SD. Evidence for a cerebral
effect of the hepatitis C virus. Lancet.
2001;358:38-9.
- Patel N,
Forton DM, Coutts GA, Thomas HC, Taylor-Robinson
SD. Intracellular pH measurements of the whole
head and the basal ganglia in chronic liver
disease: a phosphorus-31 MR spectroscopy study.
Metab Brain Dis. 2000;15:223-40.
- Hoare JM,
Forton DM. Current concepts in viral hepatitis.
J R Coll Physicians Lond. 2000;34:481-4.
- Thomas HC,
Torok ME, Forton DM, Taylor-Robinson SD.
Possible mechanisms of action and reasons for
failure of antiviral therapy in chronic
hepatitis C. J Hepatol. 1999;31 Suppl 1:152-9.
BOOK CHAPTERS
- Matthews H,
Forton DM. Extrahepatic Manifestations in
Hepatitis C Virus Guide, edited by Karayiannis,
Main and Thomas, International Medical Press,
2008
- Forton DM,
Taylor-Robinson SD, Cox IJ, Thomas HC. Central
Nervous System Complications of Hepatitis C
Virus Infection in Viral Hepatitis, 3rd Edition,
edited by Zuckerman and Thomas, Churchill
Livingstone 2005.
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